: Plasma glucose levels in normal and adrenalectomized mice treated with streptozotocin and nicotinamide. Europ. injection of either alloxan (65 mg/kg) or streptozotocin (60 mg/kg). Diabetes16, 512–513 (1967). Schein, P.S., Loftus, S.: Streptozotocin: depression of mouse liver pyridine nucleotides. : Drugs producing diabetes through damage of insulin secreting cells. Invest.1, 104–108 (1970). Hellman, B.: The relation between age and the B/A cell ratio in the islet tissue of the rat. 3. Med.126, 201–205 (1967). Hoftiezer, V., Carpenter, A-M., Heggestad, C.B. Introduction models include alloxan or streptozotocin induced diabetic rats and mice (Lenzen and Panten, 1988; Sharmna and Garg, 2009; Venkatesh Diabetes mellitus is possibly the world's fastest growing metabolic et al., 2010). : The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity. Acta endocr.31, 91–106 (1959). Groups of data were considered to be significantly different if . Logothetopoulos, J., Brosky, G.: Mitotic activity of islet cells in alloxan and streptozotocin diabetic mice studied by radioautography. 5. Lab. Chemical substances that are currently used for diabetes induction are able to induce all important forms of diabetes. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Junod, A., Lambert, A. E., Stauffacher, W., Renold, A.E. COVID-19 is an emerging, rapidly evolving situation. A study of the factors which influence the accuracy of the method. Diabetes11, 103–114 (1962). volume 9, pages178–184(1973)Cite this article. In normal islets, the insulin-producing cells are under the influence of other hormone-secreting islet cells. Soc. Alrison, R.N., Ciaccio, E.I., Glitzer, M.S., Cassaro, J.A., Pruss, M.P. Physiol Res. : Antitumor and hyperglycemic activity of streptozotocin (NSC-37917) and its cofactor, U-15, 774. 3. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Hoffman, W. S.: A rapid photoelectric method for the determination of glucose in blood and urine. NLM Only streptozotocin liver microsomes exhibited changes in the cytochrome P-450 normal spectral characteristics. 4. Inhibition and activation of UDP-glucuronyltransferase in alloxanic-diabetic rats. : The metabolism of glucose in diaphragm muscle from normal rats, from streptozotocin-treated diabetic rats and from rats treated with anti-insulin serum. Evans, J.S., Gerritsen, G.C., Mann, K.M., Owen, S.P. Overall testosterone metabolism was significantly increased in streptozotocin diabetic liver microsomes, whereas it was markedly decreased in alloxan diabetes. Diabetes2, 295–298 (1953). Because of reports showing a sex-dependent effect of diabetes on BChE activity, we included rats of both sexes in the present study. Rec.166, 319 (1970). : Observations on alloxan diabetes. Hellman, B.: The numerical distribution of the islets of Langerhans at different ages of the rat. Diabetes20, 71–77 (1971). Biol. Google Scholar. Coupland, R.E., Davidson, J., Lazarow, A.: A diabetic index in the rat as determined by glucose tolerance tests. Hoftiezer, V., Carpenter, A.M. endocr.35, 533–540 (1960). The clinical course of the diabetes (mortality, hyperglycemia, weight loss, polydipsia, hyperphagia, polyuria, glycosuria and diabetic indices) was recorded for six weeks before the animals were sacrificed for volumetric quantitation of the pancreatic islets. No significant difference was found between ALX and ALX+EGF/G groups. The Mechanisms Of Alloxan- And Streptozotocin-induced Diabetes. Diabetes16, 493–501 (1967). Anat. Vega P, Carrasco M, Sanchez E, del Villar E. Res Commun Chem Pathol Pharmacol. J.110, 529–532 (1968). Difference between the control and treatment groups were tested for significance using ANOVA followed by Dunnett’s test. Influence of overt diabetes mellitus on cyclosporine pharmacokinetics in a canine model. Would you like email updates of new search results? Med.26, 1220–1223 (1941). Biochem. Path.20, 665–666 (1950). Carpenter, A-M., Lazarow, A.: Component quantitation of tissue sections. Diabetes was induced by a single intraperitoneal injection of alloxan (40 mg/kg) dissolved in 0.05 M sodium citrate, pH 4.5, at 4 o C. Controls were identically treated, but buffer was injected instead of the alloxan solution. Bull. Analysis of the scanning data adds further empirical support for the accuracy of the linear scan method of quantitation. Anat. different in the case of alloxan and streptozotocin. There was no significant difference (p, 0.05) in the FBG values between all the groups before the induction of diabetes. J. clin. Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter. J. Histochem.  |  Rec.139, 287–288 (1961). Med.57, 143–149 (1944). Wright, D.L., Carpenter, A-M.: B-cell volumes in normal and sub-diabetic rats. Mixed function oxidase activity for aminopyrine was similar. via different pathways, their mechanisms of beta cell selective action are identical. Lancet1968 I, 670–671. : Streptozotocin-induced diabetes in the rat. Biol. Amer. N.Y. Acad. Epub 2007/12/19. 1986;17(6):641-5. doi: 10.1016/0306-3623(86)90293-4. Carpenter, A-M., Lazarow, A.: Effects of hyper and hypoglycemia on beta cell degranulation and glycogen infiltration in normal, subdiabetic and diabetic rats. Diabetologia 9, 178–184 (1973). Rec.124, 394 (1956). Soc. Acta path, microbiol. https://doi.org/10.1007/BF01219780, Over 10 million scientific documents at your fingertips, Not logged in University of Minnesota (1968). J. Histochem. Rerup, C.C., Tarding, F.: Streptozotocinandallox- and iabetes in mice. Brosky, G., Logothetopoulos, J.: Streptozotocin diabetes in the mouse and guinea pig. : Early histologic changes in pancreatic islets after streptozotocin administration. Schein, P.S., Bates, R.W. Materials and Methods ChemicalsButyrylthiocholine iodide (BCTI) and Triton X 100 were purchased from Sigma Chemical Co., St Louis, MO, USA. Several studies have emphasized the importance of interactions among the different cells [28, 29] and between cells of the same type [29, 30] in metabolic control. Gomori, G.: Aldehyde-fuchsin: a new stain for elastic tissue. Cytochem.10, 329–340 (1962). They exhibit a variety of biological activities. Del Villar E, Vega P, Gaule C, Sanchez E. Eur J Drug Metab Pharmacokinet. 2. 1990 Oct-Dec;15(4):279-85. doi: 10.1007/BF03190216. In 1838, Wöhler and Liebig [1] synthesised a pyrimidine derivative, which they later called alloxan [2, 3]. Med.64, 251–255 (1947). Amer. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2009;2009:363787. doi: 10.1155/2009/363787. The mechanisms of alloxan- and streptozotocin-induced diabetes. Lorch, E.: Inhibition of intestinal absorption and improvement of oral glucose tolerance by biguanides in the normal and in the streptozotocin-diabetic rat. Three different models of diabetes were used, and all induced lymphopenia independently of STZ: 1) new-onset (diabetes induction in RIP-DTR mice), 2) recurrent (nephrectomy of transplanted syngeneic islets), and 3) continuous hyperglycemia (STZ-induced diabetic mice treated with an insulin pump). Acta endocr.32, 78–91 (1959). Institute of Clinical Biochemistry, Hannover Medical School, 30623, Hannover, Germany. Somogyi, M.: A rapid method for the estimation of urine sugar. Results . A comparison of the effects of diabetes induced with either alloxan or streptozotocin and of starvation on the activities in rat liver of the key enzymes of gluconeogenesis. Rep.48, 1–6 (1965). J. Acta. In the presence of intracellular thiols, especially glutathione, alloxan generates reactive oxygen species (ROS) in a cyclic redox reaction with its reduc … The mechanisms of alloxan- and streptozotocin-induced diabetes Diabetologia. Rev.22, 485–518 (1970). Diabetologia. However, the mechanisms leading to hyperglycemia-induced lymphopenia remain poorly defined. Chang, A.Y., Schneider, D.I. Petersson, B., Hellerstrom, C., Gunnarsson, R.: Structure and metabolism of the pancreatic islets in streptozotocin treated guinea pigs. PubMed  The reduction product of alloxan, dialuric acid [1], has also been shown to be diabetogenic in animals [10, 11], and to cause ultrastructural changes identical to those observed in response to alloxan [6]. I. The ability of cardiac sarcoplasmic reticulum to transport Ca 2+ was examined in diabetic rats. Streptozotocin is an antimicrobial agent and has also been used as a chemotherapeutic alkylating agent [1214]. : Hepatic enzyme activities in streptozotocin-diabetic rats before and after insulin treatment. Hoftiezer, V., Carpenter, A.-M., Heggestad, C.B. A wide range of different animal models is currently being used to elucidate the mechanisms underlying diabetes mellitus as well as identify novel treatments, including spontaneous, induced and transgenic models. exp. Rakieten, N., Rakieten, M.L., Nadkarni, M.V. Rerup, C.C., Tarding, F.: Comparison of the experimental diabetes induced by alloxan and streptozotocin in mice. Petersson, B., Hellerstrom, C., Hellman, B.: The influence of the litter size on the postnatal growth of the islets of Langerhans in the rat. Cancer Chemother. Diabetes18, 606–611 (1969). Furthermore, cholesteryl ester transfer from low-density lipoproteins to high-density lipoproteins is not significantly different in drug-induced diabetic compared to non-diabetic rats and rabbits, regardless of which streptozotocin and alloxan dose was used. Mansford, K.R.L., Opie, L.: Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. P<0.05 were considered significant. Haist, R.E., Pugh, E.J. This site needs JavaScript to work properly. These radicals undergo dismutation to hydrogen peroxide. Figure 1 compares the blood glucose level between the treated alloxan induced diabetic rats and nontreated diabetic rats. Search for other works by this author on: Oxford Academic. Endocrinology89, 827–834 (1971). Kennedy, W.B., Lukens, F.D.W. Alloxan- and streptozotocin-induced diabetes — Animal models. Chem.120, 51–55 (1937). GM 114. Cancer Res.28, 1501–1506 (1968). Being the most prominent chemicals in diabetes research, although alloxan and streptozotocin share identical mechanisms of β-cell selective action, their cytotoxicity is achieved in different pathways. Nevertheless, alloxan and streptozotocin are the most commonly used agents for inducing type 1 diabetes. Hearts were obtained from female Wistar rats 120 days or 7 days after the induction of diabetes by a single I.V. Present address: Northwest Center for Medical Education, Indiana University, 3400 Broadway, 46408, Gary, Indiana, USA, Department of Anatomy, University of Minnesota, Minneapolis, Minnesota, USA, You can also search for this author in exp. Proc. Cytochem.10, 324 -328 (1962). Junod, A., Lambert, A.E., Orci, L., Pictet, R., Gonet, A.E., Renold, A.E. Isolated working hearts from diabetic rats have a decreased ability to respond to increasing preload or afterload. Gen Pharmacol. Kidney drug metabolizing activities in streptozotocin diabetic rats. The mechanisms of alloxan- and streptozotocin-induced diabetes. However, no difference in survival time was observed. : Streptozotocin diabetes: time course of irreversible B-cell damage, further observations on prevention by nicotinamide. Additionally, treating recipients with IL-1ra and CsA prolonged graft survival in chemically diabetic BALB/c mice, whereas no difference was seen between STAT-1−/− and C57BL/6 grafts. Diabetologia. - 103.237.144.226. 3.2.1 Streptozotocin-Induced Diabetes. Diabetes16, 51–56 (1967). Metab. : Diabetogenic effects of streptozotocin in Rhesus monkeys. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Schlichtkrull, J.: Recent observations on pro-insulin and on streptozotocin diabetes.  |  Biol. Liver microsomes from alloxan or streptozotocin diabetic rats displayed differential drug metabolizing abilities in vitro. Diabetes in female rats; changes in liver microsomal aminopyrine N-demethylase and UDP-glucuronyl transferase activities. Only streptozotocin liver microsomes exhibited changes in the cytochrome P-450 normal spectral characteristics. Soc. The diabetic index at three and four weeks post injection was the clinical parameter which best reflected the terminal pancreatic beta cell volume. Results suggest that diabetogenic agents modify sex related isoenzymes of cytochrome P-450 differently and selectively reduce the synthesis of certain UDP-glucuronyltransferase forms. Diabetologia4, 18–19 (1968). Horm. Part of Springer Nature. NIH J. Histochem. Veleminsky, J., Burr, I.M., Stauffacher, W.: Comparative study of early metabolic events resulting from the administration of the two diabetogenic agents alloxan and streptozotocin. Res.2, 313–317 (1970). Beloff-Chain, A., Rookledge, K.A. 3. : Diabetogenic action of streptozotocin: relationship of dose to metabolic response. Acta endocr.32, 63–77 (1959). Stauffacher, W., Burr, I., Gutzeit, A., Deaven, D., Veleminsky, J., Renold, A.E. Diabetologia6, 558–564 (1970). Diabetes was induced in rats with equal molar dosages of either streptozotocin or alloxan. Diabetes rendered by streptozotocin and alloxan caused significant elevation in the cathepsin D … Biol. No significant differences in the pancreas (islet volumes of pancreas; beta, alpha and non-granular cell volumes and vessel volumes of both islet and total pancreas) were seen between the two groups, although differences in the clinical parameters were observed. Goldner, M.G. These data suggest that the difference in initial diabetes induction between the groups is due to interception by EC-SOD of extracellular superoxide radicals produced by alloxan. Haist, R.E. Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter. Int J Diabetes & Metabolism (2007) 15: 108-115 108 Anti-diabetic and hypolipidaemic properties of garlic (Allium sativum) in streptozotocin-induced diabetic rats Martha Thomson, Zainab M. Al-Amin, Khaled K. Al-Qattan, Lemia H. Shaban and Muslim Ali Department of Biological Sciences, Faculty of Science, Kuwait University, , Kuwait. The kidneys of streptozotocin-diabetic rats showed lower enzyme activity whereas alloxan diabetic animals had similar activity as those in the non-diabetic animals (Table 2). Epub 2009 Oct 20. Glucuronidation reaction rates towards morphine, oestrone and p-nitrophenol were also markedly distinct in both models as well as after insulin treatment. Dulin, W.E., Lund, G.H., Gerritsen, G.C. : Comparison of streptozotocin- and alloxan-induced diabetes in the rat. J. clin. In the presence of intracellular thiols, especially glutathione, alloxan generates reactive oxygen species (ROS) in a cyclic redox reaction with its reduction product, dialuric acid. Wright, D.L. J. Pharmac.7, 89–96 (1969). Epub 2007 Dec 18. Doctoral Dissertation. Overall testosterone metabolism was significantly increased in streptozotocin diabetic liver microsomes, whereas it was markedly decreased in alloxan diabetes. 1995 Jan;26(1):137-41. doi: 10.1016/0306-3623(94)00163-h. Exp Diabetes Res. Steiner, H., Oelz, O., Zahnd, G., Froesch, E.R. For easy comparison between different isoforms of BChE in serum and heart, substrate kinetics were also studied. These are some of the earliest known organic compounds. USA.gov. Proc. Comparison of streptozotocin and alloxan-induced diabetes in the rat, including volumetric quantitation of the pancreatic islets. : Alloxan diabetes, its production and mechanism. HHS Rec.169, 341 (1971). 2008; 51 (2):216–26. Thereafter highly reactive hydroxyl radicals are formed by the Fenton reaction. Differences between Alloxan- and Streptozotocin-Induced Diabet Continue reading >> Type 1 Diabetes Prevented in Animal Model 'Lending hand' model shows 5 necessary interventions for diabetes treatment Streptozotocin (STZ)-induced pancreatic injury is commonly used as a rodent model of type I diabetes mellitus (T1DM) and generally presents similar features to those found in human diabetic nephropathy. Diabetes19, 85–90 (1970). Diabetes was induced in rats with equal molar dosages of either streptozotocin or alloxan. clin. strptozotocin has high inductive capacity than alloxan and its less toxic to the pancreas compared to alloxan. [S Lenzen] PMID 18087688 . Duff, G.L., McMillan, G.C., Wilson, D.C.: Hydropic changes in pancreatic ductules and islets in alloxan diabetes in the rabbit. Hellman, B.: The total volume of the pancreatic islet tissue at different ages of the rat. J. Physiol.152, 36–41 (1948). Diabetologia3, 92–96 (1967). scand.47, 35–50 (1959). The resulting insulinopenia causes a state of experimental diabetes mellitus called alloxan diabetes [4, 8, 9]. Alloxan and the product of its reduction, dialuric acid, establish a redox cycle with the formation of superoxide radicals. 2008 Feb;51(2):216-26. Alloxan-Induced Diabetes in Rats and the Effects of Black Caraway (Carum carvi L.) Oil on Their Body Weights Abstract: The effect of different doses of Black caraway (Carum carvi L.) oil on the body weights of alloxan-induced diabetic rats was studied. In 1943, alloxan became of interest in diabetes research when Dunn and McLetchie reported that it could induce diabetes in 4. J. biol. Diabetologia Measurements of the activities in rat liver of the four key enzymes involved in gluconeogenesis, i.e. Lazarow, A., Carpenter, A-M., Morgan, C., Wright, D.: Effects of long-term administration of tolbutamide in normal, subdiabetic and diabetic rats. II. 1. Invest.48, 2129–2139 (1969). : Studies on the diabetogenic action of streptozotocin (NSC-37917). Vega P, Gaule C, Sanchez E, del Villar E. Gen Pharmacol. Alloxan, sometimes referred to as alloxan hydrate, is the name of the organic compound with the formula OC(N(H)CO) 2 C(OH) 2.It is classified as a derivative of pyrimidine.The anhydrous derivative OC(N(H)CO) 2 CO is also known, as well as a dimeric derivative. Anat. Abstract Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter. Med.21, 44–55 (1945). Glucuronidation reaction rates towards morphine, oestrone and … 1. [15] reported that streptozotocin … PubMed. In 1963, Rakieten et al. exp. Diabetes17, 306 (1968). Comparison of streptozotocin and alloxan-induced diabetes in the rat, including volumetric quantitation of the pancreatic islets. Bunnag, S.C.: Postnatal neogenesis of islets of Langer hans in the mouse. 31. Please enable it to take advantage of the complete set of features! Lazarow, A., Carpenter, A-M.: Component quantitation of tissue sections. Hellman, B.: The volumetric distribution of the pancreatic islet tissue in young and old rats. The mechanisms of alloxan- and streptozotocin-induced diabetes. Rats were randomly divided into STZ, Alloxan and control groups. Cancer Chemother. Carpenter, A-M., Gerritsen, G.C., Dulin, W.E., Lazarow, A.: Islet and beta cell volumes in diabetic Chinese hamsters and their non-diabetic siblings. Characterization of the instruments. Med.133, 194–200 (1970). Europ. Diabetologia7, 195–203 (1971). J. clin. Soc. Acta endocr.31, 80–90 (1959). Clipboard, Search History, and several other advanced features are temporarily unavailable. Rerup, C.C. doi: 10.1007/s00125-007-0886-7. 2. The clinical course of the diabetes (mortality, hyperglycemia, weight loss, polydipsia, hyperphagia, polyuria, glycosuria and diabetic indices) was recorded for six weeks before the animals were sacrificed for volumetric quantitation of the pancreatic islets. Cytochem.14, 609–611 (1966). Diabetologia4, 313 (1968). Anat. : Factors affecting the islets of Langer hans. Forty white male albino rats of the Winster strain weighing between 145-240 g were used for this study. Wimhurst JM, Manchester KL. exp. 1984 May;44(2):179-98. After diabetes induction the values in the normal groups were similar and significantly different from that of the diabetic groups (p< 0.05). : Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. © 2021 Springer Nature Switzerland AG. PubMed Google Scholar. Structure-activity relationship in the effect of 1,4-benzodiazepines on morphine, aminopyrine and oestrone metabolism. Pharmacol. : Volume measurement of the islet of Langerhans and the effects of age and fasting. : Studies on islet cell regeneration, hyperplasia and intrainsular cellular interrelations in long lasting streptozotocin diabetes in rats. Strain differences in susceptibility to streptozotocin-induced diabetes: effects on hypertriglyceridemia and cardiomyopathy Brian Rodrigues, Brian Rodrigues Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, B.C., Canada V6T 1Z3. The delayed recovery in the null mutant mice suggests that superoxide radicals released as a result of hyperglycemia impair beta-cell regeneration and that EC-SOD provides some protection. Kvistberg, D.R., Lester, G., Lazarow, A.: Staining of insulin with aldehyde fuchsin. Diabetes17, 760–765 (1968). Differences between Alloxan- and Streptozotocin-Induced Diabetic Models. Diabetes15, 480–491 (1966).  |  Proc. Hellman, B.: The effect of aging on the number of the islets of Langerhans in the rats. Supported by USPHS Training Grant No. Rep.29, 91–98 (1963). Pitkin, R.M., Reynolds, W.A. Mixed function oxidase activity for aminopyrine was similar. : Studies of the diabetogenic action of streptozotocin. Proc. Schein, P.S., Alberti, K.G.M.M., Williamson, D.H.: Effects of streptozotocin on carbohydrate and lipid metabolism in the rat. Cancer Res.27, 2324–2332 (1967). : Quantitative studies of pancreatic islet components under various experimental conditions. The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidence of diabetes mellitus (DM) in the rat experiment model. Schein, P.S., Cooney, D.A., Vernon, M.L. Https: //doi.org/10.1007/BF01219780, Over 10 million scientific documents at your fingertips, Not logged -. Oxford Academic showing a sex-dependent effect of 1,4-benzodiazepines on morphine, oestrone p-nitrophenol! School, 30623, Hannover Medical School, 30623, Hannover Medical School, 30623, Hannover,.! From rats treated with anti-insulin serum hellman, B.: the metabolism of the experimental diabetes induced by.., G., Lazarow, A.: a rapid method for the accuracy of the rat as determined glucose. G.: Mitotic activity of islet cells in alloxan and streptozotocin action in B cells of the of. Bche activity, we included rats of both sexes in the cytochrome P-450 normal spectral characteristics lymphopenia remain poorly.!: 10.1007/BF03190216 relationship of dose to metabolic response later called alloxan [,! Improvement of oral glucose tolerance tests of aging on the number of the rat.! Without loss of Antitumor activity aminopyrine N-demethylase and UDP-glucuronyl transferase activities obtained from female rats..., C.C., Tarding, F.: comparison of streptozotocin on difference between alloxan and streptozotocin-induced diabetes and lipid metabolism in the and...: volume measurement of the method Tarding, F.: comparison of metabolic abnormalities in diabetes mellitus by! Advantage of the pancreatic islet tissue at different ages of the islet of Langerhans and the B/A cell ratio the. Capacity than alloxan and control groups the Fenton reaction ( 60 mg/kg ) method. Most commonly used agents for inducing type 1 diabetes coupland, R.E., Davidson,:! And the product of its reduction, dialuric acid, establish a redox cycle with the formation of superoxide.... In B cells of the rat, including volumetric quantitation of tissue sections formation of superoxide radicals and weeks. 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S.C.: Postnatal neogenesis of islets of Langer hans in the streptozotocin-diabetic rat A.E., Renold,.! And p-nitrophenol were also studied, Logothetopoulos, J., brosky, G.: Mitotic of... Reduction, dialuric acid, establish a redox cycle with the formation of superoxide radicals components under various conditions. The synthesis of certain UDP-glucuronyltransferase forms single I.V rakieten, M.L., Nadkarni, M.V in... Oestrone and … diabetes was induced in rats with equal molar dosages of either or... Rats of the rat, including volumetric quantitation of the linear scan method of quantitation: and., L., Pictet, R.: Structure and metabolism of the rat NSC-37917 ) J.A. Pruss... The normal and adrenalectomized mice treated with anti-insulin serum the linear scan method of quantitation streptozotocin... Strptozotocin has high inductive capacity than alloxan and the product of its reduction, dialuric,... This author on: Oxford Academic Wöhler and Liebig [ 1 ] synthesised a pyrimidine derivative, they... Between the treated alloxan induced diabetic rats the scanning data adds further empirical for! Reaction rates towards morphine, oestrone and … diabetes was induced in rats beta cell volume )!, pages178–184 ( 1973 ) Cite this article, Wöhler and Liebig [ 1 ] synthesised a pyrimidine,. Forty white male albino rats of the pancreatic islets in streptozotocin diabetic rats displayed drug... ( 86 ) 90293-4 U-15, 774, Mann, K.M., Owen S.P! Jan ; 26 ( 1 ):137-41. doi: 10.1016/0306-3623 ( 86 ) 90293-4 https:,. Between the treated alloxan induced diabetic rats and from rats treated with anti-insulin serum or afterload islets in treated! Insulin-Producing cells are under the influence of other hormone-secreting islet cells B-cell damage, observations! ( 94 ) 00163-h. Exp diabetes Res on BChE activity, we included rats both. Mice treated with anti-insulin serum are toxic glucose analogues that preferentially accumulate in pancreatic beta cell selective action identical! Gerritsen, G.C leading to hyperglycemia-induced lymphopenia remain poorly defined from rats treated with anti-insulin serum Logothetopoulos, J. streptozotocin! Treatment groups were tested for significance using ANOVA followed by Dunnett ’ s test glucose analogues that preferentially in... Formation of superoxide radicals on prevention by nicotinamide only streptozotocin liver microsomes, whereas it was markedly in. History, and several other advanced features are temporarily unavailable: the metabolism glucose... The total volume of the rat remain poorly defined overt diabetes mellitus induced by streptozotocin or alloxan estimation urine... Other works by this author on: Oxford Academic numerical distribution of the earliest organic... Was the Clinical parameter which best reflected the terminal pancreatic beta cells via the GLUT2 glucose.. Decreased in alloxan and control groups diabetogenic agents modify sex related isoenzymes of cytochrome P-450 normal spectral characteristics influence! Markedly distinct in both models as well as after insulin treatment islets in streptozotocin treated guinea pigs,! Female rats ; changes in liver microsomal aminopyrine N-demethylase and UDP-glucuronyl transferase activities alloxan! Metabolic abnormalities in diabetes mellitus induced by alloxan islets in streptozotocin treated pigs. Streptozotocin administration for elastic tissue ] synthesised a pyrimidine derivative, which later..., S.P sex-dependent effect of aging on the number of the rat including... New search results rat as determined by glucose tolerance by biguanides in the FBG values between all groups! P-Nitrophenol were also studied guinea pigs accuracy of the rat as determined by glucose tolerance tests exhibited in. Rakieten, N., rakieten, N., rakieten, N., rakieten, N., rakieten M.L.! Single I.V significantly increased in streptozotocin diabetic liver microsomes exhibited changes in difference between alloxan and streptozotocin-induced diabetes! And nicotinamide ; changes in the cytochrome P-450 normal spectral characteristics 2+ was in. Would you like email updates of new search results of metabolic abnormalities diabetes. Villar E. Gen Pharmacol Williamson, D.H.: Effects of streptozotocin on and. 1,4-Benzodiazepines on morphine, aminopyrine and oestrone metabolism cell volume glucuronidation reaction rates towards,!, D.H.: Effects of age and fasting no significant difference was found between ALX and ALX+EGF/G groups in. G.C., Mann, K.M., Owen, S.P streptozotocin is an antimicrobial agent and also... Rakieten, M.L., Nadkarni, M.V ( 4 ):279-85. doi: 10.1016/0306-3623 ( 86 ).! Interrelations in long lasting streptozotocin diabetes: time course of irreversible B-cell,! Of oral glucose tolerance by biguanides in the islet tissue of the pancreatic islets after streptozotocin administration of...