It has been reported that the seeds have anti-inflammatory [6] and antitumor activity [7] and that the nucleus in the seeds can improve blood circulation [8]. The mast cell density at each site was calculated and recorded as MC numbers mm−2. Xi'an Henrikang Biotech Co., Ltd. (123) ... Chan Shan Tao Ren Factory Supply Crude Medicine Chinese Herbs Prunus Davidiana Seeds,Wild Peach Seeds . The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. Pretreatment with NE (1 μM) did not inhibit the EAE-induced contraction (Figure 2), suggesting that adrenergic pathways are not involved in EAE-induced contraction. How might this impact on policy or clinical practice in the foreseeable future? The cultivated/domesticated peach (Prunus persica var. Fruit: Cool, moist Classifications: 2A APERIENT 3D. Gastrointestinal diseases are common public health issues worldwide and gut motility disorders, including indigestion and constipation, are considered to be major causes of ill-health [1]. Recently, it is shown that the polyphenolic extract of Prunus persica fruit can suppress breast cancer cell proliferation and tumor growth [8, 9]. To. Him-Che. It bears edible juicy fruits with various characteristics, most called peaches and others, nectarines. Tea Leaf Essentials Wellness Korean Tea Gentle Cleanse. … [28] DIURETIC. Taorenni ÌÒÈÊÄà Chinese Name (pinyin): Taoren Chinese Name : Common Name :Peach Kernel Specific Name : Semen persicae Scientific Name: Collection : The fruit is collected when ripe, the seed is removed from sarcocarp and shell (endocarp) and dried in the sun. Temperature & Taste: Kernel: Neutral in TCM (slightly Warm in the West); Moist. Our findings suggested that TSG may serve as a source to isolate anti-HCC therapeutic ingredients. Mast cell analysis and measurement of histamine levels in rat colon tissues confirmed that the mechanism underlying the gastrointestinal activity involves release of histamine from mast cells. (a) Omission of primary antibody. All WHP single remedies are made to order; thus, the labels are printed on the same label stock as the orders are filled. [28] [29] It has long been used as a traditional drug and healthy food in East Asian countries. This makes deep exploration of the tumor suppression role of root of Prunus persica difficult. The proposed electrochemical oscillation system was then used for the identification of P. persica, P. davidiana, and P. armeniaca. Medicinal herbs: Peach (Prunus persica) ... Prunus persica. 2015, Article ID 569853, 10 pages, 2015., 1Department of General Surgery, Hepato-Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou 730030, China, 2Department of Physiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China, 3Disease Control and Prevention Center of Qingan, Tianshui 741600, China, 4Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China. Five populations of archaeological peach stones recovered from Zhejiang Province, China, document peach use and … HepG2 cells were seeded onto 6-well plate at a density of per well. The muscle strips were bathed with Krebs solution (5 mL) recirculating from a chamber maintained at °C during the experiments. Prunus persica var. Plant, 9 (3): 356-370 Crossref, … In the presence of atropine, the contractile effect of EAE was not blocked, indicating that cholinergic pathways are not responsible for the stimulant effect. 24 hours later, medium was replaced with fresh growth medium containing 10% of the above cell viability assay reagent and incubated for 1 hour. The gastrointestinal activity of EAE in rats was found to be mediated by effects on spontaneous smooth muscle contractions in isolated rat colonic tissue. Prunus persica (L.) Batsch, peach tree or taoshu in Chinese, originated from Northwest China and nowadays is a worldwide cultivated fruit plant [4]. Natutal medicine can heal your body and mind. Root of Prunus persica is applied to treat jaundice, hematemesis, hemorrhoids, amenorrhea, and tinea in Chinese medicine. Simultaneously, the concentration of histamine remaining in the colon tissue was examined. scleropersica (Reich.) Expected size. Atropine, a muscarinic receptor antagonist, was also used to explore the mechanism of the EAE-induced contraction. Keishi-bukuryo-gan (TJ-25) is a traditional Chinese herbal remedy containing five components: bark of Cinnamomum cassia, root of Paeonia lactiflora, seed of Prunus persica or P. persiba var. Ku-35 significantly inhibited the release of UVB-induced arachidonate acid metabolites Address all correspondence to Hyun Pyo Kim. The preliminary In experience-based folk medicine, root of Prunus persica is also included in the prescription to ameliorate esophageal cancer . Cell migration status was monitored at indicated time point under microscope and represented by the recovery of the scratch. As increased migration is another important feature of cancer cell, we then turned to investigate the influence of TSG on migration ability of HepG2 cells. Bitter, Sweet Leaf, Flower: Warm, dry. Despite a long history of the use of Prunus persica (L.) Batsch flowers in traditional Chinese medicine, few studies have explored the pharmacological effect of these preparations on gastrointestinal motility or the underlying mechanism of action. Other allergens with different molecular weights have been also identified. We further investigated the mechanism underlying the action of EAE on muscle contractions. Different herbs are used to restore this balance, achieving the goal of treatment. As shown in Figures 3(a) and 3(b), TSG-treated cells demonstrated notable compromised migration since early 6 hours after drug administration. Park, J.-S. Yoo et al., “Anti-allergic inflammatory activity of the fruit of, T. Fukuda, H. Ito, T. Mukainaka, H. Tokuda, H. Nishino, and T. Yoshida, “Anti-tumor promoting effect of Glycosides from, L. Liu, J.-A. The nuts of Prunus persica, Prunus davidiana, and Prunus armeniaca have been widely used for medical purposes. In line with the previous report in liver cancer cell SMMC7721 and SK-HEP-1, our data indicated that root of Prunus persica extract also induced a dose and time-dependent growth inhibition of HepG2 cells. 3F. Medicinal herbs; Natural herbs; Latin names; Common names; Herb: Peach Latin name: Prunus persica Synonyms: Amygdalis persicus, Persica vulgaris Family: Rosaceae (Rose Family) Medicinal use of Peach: Antihalitosis. Control sample of rat colon ((a) magnification ×100; (b) ×400). It has been reported that adrenergic pathways can modulate gut motility [19] but we found that the contractile effect of EAE was not influenced by NE, a nonselective adrenergic agonist, suggesting that the EAE-induced effect is not mediated through adrenergic pathways. It has been reported that adrenergic pathways can modulate gut motility [19]. However, the current chemotherapy agents remain ineffective and present wide side effects for advanced HCC patient. Mast cells were determined in the EAE-treated group and control group. Subject. US $16.80-$33.60 / Kilogram 1 Kilogram (Min. Persica is none other than the inner kernel of the common peach (Prunus persica), known in China as tao (ren = seed). It is described to have the function to treat disease like jaundice, hematemesis, hemorrhoids, amenorrhea, and tinea in classical Chinese medical documents and also used in nowadays Chinese medicine application. Petroleum ether, chloroform, ethyl acetate, and n-butanol were purchased from Beijing Chemical Works (Beijing, China). In contrast, the addition of DMSO had no effects on cellular migration compared with the control (blank) (Figures 3(a)–3(g)). Thus, it should be a good source to explore novel HCC chemotherapy agent. spring. Beautiful spring flowers, lush foliage through summer, juicy fruits, golden fall color - Peach or nectarine trees (Prunus persica) are a beautiful sight across seasons. All WHP single remedies are made to order; thus, the labels are printed on the same label stock as the orders are filled. scleronuci persica (Schübler & Martens) Yü et Lu; Prunus persica var. (b) Detection of tryptase in control group. In experience-based clinical application, root of Prunus persica was also applied to treat esophageal cancer [13]. Easy care. Furthermore, immunofluorescence and toluidine blue staining revealed increased numbers of mast cells in the EAE group, and EAE increased histamine release from the colonic tissues. Following pretreatment of rat colon tissues with EAE, the histamine content in the supernatant was higher than that in the control group. For western blotting, cells were seeded onto 6 cm dish. The concentration of the stock ethanol extract of TSG is 0.086 g/ml which almost reaches saturation. The Effect of Semen Persicae Property. However, more advanced evidence is required before EAE is employed as a potential therapeutic drug in the clinic. To begin the anti-HCC activity investigation of root of Prunus persica, we firstly performed the ethanol extraction of root of Prunus persica (TSG thereafter). Animals in the experimental group were treated with EAE (0.9 g/kg) by gastric administration each day for 7 days based on our preliminary experiment; animals in the control group received the same volume of distilled water at the same dosing intervals. This study aims to identify the active compounds of ISF-1 for the induction of follistatin expression. The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. Prunus persica is an important source of medicinal materials in traditional Chinese medicine. In consideration of a maximum administration dosage, the maximum volume tolerance of intragastrical drug administration and avoiding hazards from high concentration of ethanol, the stock TSG ethanol extract was diluted 10-fold with distilled water (finally in 10% ethanol) and intragastrically administrated to nude mice in 0.5 ml/day (with a final dosage of 4.3 mg/day). And the manuscript will be submitted … And, hepatocellular carcinoma (HCC) is the most common primary liver cancer [1]. TSG treatment induced G2/M phase arrest of HepG2 cells. Tan, S.-Q. The study has not been published yet. Our data suggest that EAE has a significant stimulatory effect on spontaneous smooth muscle contractions in isolated rat colonic tissue. These data indicate that EAE has significant prokinetic activity and acts by a mechanism that mainly involves mast cell degranulation. Chinese emperors used to give their immortal gods ‘peaches of immortality’ as offerings so as to ensure they had everlasting life. In this study, we firstly investigated the antitumor effect of ethanol extract of root of Prunus persica on the hepatocarcinoma cell HepG2. This work was supported by funding from the Science and Technology Pillar Program of Gansu Province, China (no. Several studies have revealed that extracts of Prunus persica (L.) Batsch flowers can reduce ultraviolet-induced skin damage and may be useful for protecting against ultraviolet-induced DNA damage and carcinogenesis [11, 12]. However, strictly controlled study is needed to assess the safe dosage and potential side effects before its translation to clinical application. Dried Prunus persica (L.) Batsch flowers (200 g) were extracted with 95% ethanol for 2 h. The extract was then filtered and the filtrate was concentrated using a rotary evaporator. Four separate extracts were thus obtained: a petroleum ether extract (PEE), a chloroform extract (CE), an ethyl acetate extract (EAE), and an n-butanol extract (NBE). Prunus persica (Peach) Peach trees, Nectarine Trees (Prunus persica) Previous Next. But few studies have explored the pharmacological effect of Prunus persica (L.) Batsch flowers on gastrointestinal motility. The authors confirm that they have no conflict of interests. 1 Box (10 tea bags). When you add these two ingredients you get a new formula known as Tao Hong Si Wu Tang (Peach Kernel and Saflower with Four Substances formula) that was created by the greatest scholar of blood stagnation in Chinese history. Wang et al., “Ginsenoside Rg1 inhibits angiotensin II-induced podocyte autophagy via AMPK/mTOR/PI3K pathway,”, Z. Zhang, L. Miao, C. Lv et al., “Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells,”, G. Noratto, W. Porter, D. Byrne, and L. Cisneros-Zevallos, “Identifying peach and plum polyphenols with chemopreventive potential against estrogen-independent breast cancer cells,”, D. Canistro, F. Vivarelli, S. Cirillo, G. Costa, C. Andreotti, and M. Paolini, “Comparison between in toto peach (Prunus persica L. Batsch) supplementation and its polyphenolic extract on rat liver xenobiotic metabolizing enzymes,”, P. Intaraprasong, S. Siramolpiwat, and R.-K. Vilaichone, “Advances in management of hepatocellular carcinoma,”. Following pretreatment of the colon tissue with ketotifen (100 μM) for 10 min before adding the EAE, the histamine concentration in the tissue was  ng/mL (, ), suggesting that ketotifen can inhibit EAE-induced histamine release (Figure 5(b)). The proposed EOS was then used for identification of Prunus persica, Prunus davidiana and Prunus armeniaca. Prunus persica in Traditional Chinese Medicine Background. Frost Hardy. Message The user has shared this species from India Biodiversity Portal with you. We conducted exon‐targeted resequencing of 129 genomes in the genus Prunus, mainly Japanese apricot ... (Prunus salicina), and peach (Prunus persica). 1.56 mg/ml TSG treatment for 24 hours can cause 37% growth inhibition (Figures 1(a) and 1(b)). The peach tree, Prunus persica(L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. And the manuscript will be submitted … Prunus persica Powder Natural Juicy Peach fruit Extract Powder . By cell viability assay, we showed that addition of TSG in the culture medium inhibited the cell growth of HepG2 cells in a dose and time-dependent way. However, treatment with DMSO and low-dosage TSG (0.34 mg/ml) had no influence on cell cycle (Figures 2(a)–2(c)). The study has not been published yet. (c) Detection of tryptase in EAE-treated group. Prunus persica(L.) BATSCH(Rosaceae) seeds are well known as a traditional medicine (Persicae Semen; Tounin, Taoren in Chinese) in Japan, China, and other Asian coun-tries. It was said that the fruit had magical powers and it bestowed infinite life on whoever ate them. The expression of mitosis-related protein Cdc25c was impaired upon TSG treatment. We are committed to sharing findings related to COVID-19 as quickly as possible. The EAE-treated group was found to have many more mast cells in the colon compared with the control group; the number of mast cells/mm2 increased from to (, , Figure 3). Full, even and complete. Histamine and PGs are key chemical messengers released by mast cells, and it has been reported that histamine stimulates the generation of prostaglandin F2α from smooth muscle [31]. If the colon tissues were pretreated with ketotifen (100 μM) for 10 min before adding the EAE, the histamine concentration was  ng/mL (, ), a value close to the basal level (Figure 5(a)). The animal experiment was approved by the animal ethics committee of Southwest Medical University and conformed to corresponding regulations. Sin. Recently, medicinal plants have attracted attention for the treatment of functional dyspepsia and constipation [3, 4] since there is growing evidence that the different components found in medicinal plants have the potential to act synergistically [5]. The peach is a deciduous tree native to the region of Northwest China between the Tarim Basin and the north slopes of the Kunlun Mountains, where it was first domesticated and cultivated. In East Asia, both P. persica flowers and N. nucifera leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. Association between chloroplast and mitochondrial DNA sequences in Chinese Prunus genotypes (Prunus persica, Prunus domestica, and Prunus avium). All treatments were performed in 4 replicates on the same plate. After equilibration for 1 h, increasing concentrations of PEE, CE, EAE, and NBE (10−8, 10−7, 10−6, 10−5, 10−4, and 10−3 g/mL) were added to the medium at 10 min intervals and muscle contractions were recorded. After incubation for 30 min, the supernatant was frozen at −20°C for subsequent analysis of histamine in the supernatant. In Chinese art and culture, peaches (Prunus persica) are seen as a symbol of immortality. The Peach is included by Hooker and other botanists in the genus prurnus, its resemblance to the plum being obvious.Others have classed it with the Almond as a distinct genus, Amygdalus, and others again have considered it sufficiently distinct to constitute it a separate genus, persica. Harvest. TSG suppressed HepG2 cell migration. Despite a long history of the use of Prunus persica (L.) Batsch flowers in traditional Chinese medicine, few studies have explored the pharmacological effect of these preparations on gastrointestinal motility or the underlying mechanism of action. The numbers of mast cells and the level of histamine were increased in the EAE group and the stimulatory effect of EAE was completely blocked by ketotifen. BMC Plant Biol. All experiments were approved by the Ethical Committee on Animal Care of the Lanzhou University Second Hospital and conformed to National Institutes of Health guidelines. It is described to have the function to treat disease like jaundice,hematemesis,hemorrhoids,amenorrhea,andtinea in classical Chinese medical documents and also used in nowadays Chinese medicine application. In this study, we investigated the antitumor role of ethanol extract of root of peach tree (Prunus persica (L.) Batsch and hereafter designated as TSG in short of its Chinese name), which is an important ingredient in Chinese medicine prescription, in liver cancer cell HepG2. On the other hand, we should note that the ethanol extract of root of Prunus persica used in this study is a complex mixture may containing several different therapy-effective components and also impurities. Transport across chloroplast membranes: optimizing photosynthesis for adverse environmental conditions. Next day, uniform scratch was made with a pipette tip on the culture surface with 100% cell confluence. Antibodies used in this study included rabbit anti-Cdc25c polyclonal antibody (Cat# D154112, Sangon Bio-tech, China), rabbit anti-CDK1 polyclonal antibody (Cat# D160158, Sangon Bio-tech, China), rabbit anti-MMP9 polyclonal antibody (Cat# 10375-2-AP, Proteintech, USA), rabbit anti-MMP3 polyclonal antibody (Cat# 17873-1-AP, Proteintech, USA), mouse anti--Actin monoclonal antibody (Cat# TA-09, ZSGB-Bio, China), HRP-conjugated goat anti-mouse polyclonal antibody (Cat# ZB2305, ZSGB-Bio, China), and HRP-conjugated goat anti-rabbit polyclonal antibody (Cat# ZB2301, ZSGB-Bio, China). It has also been reported that the enteric nervous system influences gastrointestinal motor activity. The nuts of Prunus persica, Prunus davidiana and Prunus armeniaca have been widely used for medical purpose. In particular, the flower of P. persica (PPF), commonly called the peach blossom, has been used as a purgative, diuretic, and cosmetic [6,7]. Phylum. Sub-Genus. However, even the first line palliative treatment medicine, sorafenib, contributes modest survival benefit (about 2.5 months) to advanced HCC patient [2, 3]. The basal concentration of histamine in colon tissue was  ng/mL (). These findings suggested that TSG induced cell cycle arrest at proper concentration. Order. To further explore the effect of histamine release by mast cells involved in EAE-induced gastrointestinal motility, we measured histamine release in rat colonic tissues treated with EAE. Sections of distal colon were equilibrated in Krebs solution with 95% O2 and 5% CO2 (1 mL) for 30 min; then EAE (10−6 g/mL) or the same volume of distilled water was added to the solution. Hongchun Shen, Honglian Wang, Li Wang, Lu Wang, Menglian Zhu, Yao Ming, Sha Zhao, Junming Fan, En Yin Lai, "Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression", Evidence-Based Complementary and Alternative Medicine, vol. Taohong Siwu decoction (THSWD) originated from the traditional Chinese medicine book Yizong Jinjian of the Qing Dynasty, which is composed of Prunus persica … Root of Prunus persica serves as another important ingredient in traditional Chinese medicine prescriptions. compressa (Loud.) Find premium, high-resolution stock photography at Getty Images. aganopersica Reich. Peach is a native of Persia and central Asia, but is widely cultivated in mild temperate climates throughout the world. There are three varieties of the Prunus persica species: peaches (clingstone, freestone and semi-freestone, with white or yellow-flesh), ... fervently writing for this site since 2014 and continues to keep up with the … The tissue segments were dried, weighed, and frozen in liquid nitrogen for subsequent analysis of histamine remaining in the tissue. Relative changes in contractile responses induced by the different concentrations of PEE, CE, EAE, and NBE relative to basal levels (before treatment with those extract) were calculated as percentages. Medicinal plants are considered to be relatively effective and safe for prolonged treatment, especially in patients with chronic gut motility disorders. The plant was identified and authenticated by Professor Sun Xuegang, Institute of Botany, School of Forestry, Gansu Agricultural University. The effect of antagonists on EAE-induced smooth muscle contraction was also determined. LITHONTRIPTIC. Super-Family. The effect on the contraction response induced by EAE was not affected by the nerve blocker, TTX, suggesting that the pharmacological effects were not mediated through the nerves. Enter search terms. CORDIALS & CARDIACS. We therefore used TTX to distinguish whether the EAE-induced increase in frequency of spontaneous contractions of isolated rat colon section was mediated by the enteric nervous system. reported that Prunus persica seed-derived glycosides showed antitumor activity in vitro and in vivo [7]. Mast cells numbers and distribution were then examined by immunofluorescence of colon sections, which can reveal circumscript staining for mast cell tryptase. Tryptase-immunoreactive mast cells were counted using a laser scanning confocal microscope (TCS SP5, Leica, Germany). Tack and S. Müller-Lissner, “Treatment of chronic constipation: current pharmacologic approaches and future directions,”, M. H. Mehmood, A. J. Al-Rehaily, R. A. 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